El lupus eritematoso sistémico (LES) es una enfermedad crónica que afecta a múltiples sistemas, entre ellos el sistema nervioso, con eventos neurológicos y psiquiátricos que podrían unir en la adherencia al tratamiento y los resultados a largo plazo de la enfermedad.Evaluar la adherencia al tratamiento de los pacientes con trastornos neuropsiquiátricos difusos asociados con el LES. Se llevó a cabo un estudio descriptivo transversal que evaluó el grado de adherencia al tratamiento con el test de Morisky en pacientes con trastornos neuropsiquiátricos difusos asociados con LES (alteración cognitiva, psicosis, trastornos del ánimo y ansiedad). Se incluyó a pacientes con trastornos neuropsiquiátricos difusos asociados con LES, de los cuales (,%) tuvieron adherencia alta,(%) adherencia media y (,%) presentaron baja adherencia al tratamiento. En este estudio se idéntico que más de la mitad de los participantes (,%) presentaron bajaadherencia al tratamiento.

Currently, the evaluation of mental disorders in patients with Systemic lupus erythematosus (SLE) is essential in the management of the illness because of their impact in morbimortality. The main purpose of this study was to determine the prevalence of mental disorders in a group of patients with SLE in a tertiary referral hospital in Quito-Ecuador. The main diffuse central nervous system psychiatric syndromes in SLE (psychosis, anxiety and mood disorders) and cognitive dysfunction were evaluated with the MINI International Neuropsychiatric Interview and the Montreal scale, respectively. This was a descriptive, cross-sectional study which included patients 15 years and older diagnosed with SLE in a tertiary referral hospital in Quito, Ecuador. 85 patients diagnosed with SLE attending the internal medicine outpatient clinic during October 2017–May 2018 were included. A bivariate analysis of possible associations between these mental disorders with corticosteroid use, antiphospholipid syndrome (APS), and quality of life was also studied. Eighty-five patients, with an average age of 34.12 ± 11.5 years were included, of which 94% were females. 71% of participants (60 patients) had at least one mental disorder evaluated in this study. The most frequent was cognitive impairment (n=43, 51%) followed by anxiety disorders (n=35, 41%), mood disorders (n=34, 40%) and psychosis (n=1; 1%). 38% presented mild cognitive impairment and 13% had moderate cognitive impairment.